U.S. Highways 30 and 67 intersect and run directly through the City of Clinton at the center of the region. These highways and nearby U.S. 61 provide direct access for the region to I-80 and I-88, main arteries that cross the United States.

Numerous state highways offer good local access for both trucks and passenger vehicles. There are more than 30 trucking and support operations in the area. United Parcel Service has a terminal on I-80 in nearby Davenport, Iowa, processing 21,000 packages hourly, producing loads for 26 delivery centers  and 24 hubs throughout the U.S. In addition, the U.S. Postal Service has a Regional Processing and Distribution Center in Moline, Illinois and Federal Express has a large hub in Moline.